Erasmus MC Rotterdam, Department of Radiation Oncology, Hyperthermia Unit, Rotterdam, The Netherlands.
Strahlenther Onkol. 2011 Dec;187(12):835-41. doi: 10.1007/s00066-011-2272-0. Epub 2011 Nov 25.
To make a patient- and treatment-specific computed tomography (CT) scan and to create a three-dimensional (3D) patient model for superficial hyperthermia treatment planning (SHTP).
PATIENTS, MATERIALS, AND METHODS: Patients with recurrent breast adenocarcinoma in previously irradiated areas referred for radiotherapy (RT) and hyperthermia (HT) treatment and giving informed consent were included. After insertion of the thermometry catheters in the treatment area, a CT scan in the treatment position was made.
A total of 26 patients have been, thus far, included in the study. During the study period, five types of adjustments were made to the procedure: (1) marking the RT field with radioopaque markers, (2) making the CT scan after the first HT treatment instead of before, (3) using an air- and foam-filled (dummy) water bolus, (4) a change to radiolucent catheters for which radioopaque markers were needed, and (5) marking the visible/palpable extent of the tumor with radioopaque markers, if necessary. With these adjustments, all necessary information is visible on the CT scan. Each CT slice was automatically segmented into muscle, fat, bone, and air. RT field, catheters, applicators, and tumor lesions, if indicated, were outlined manually using the segmentation program iSeg. Next the model was imported into SEMCAD X, a 3D electromagnetic field simulator.
Using the final procedure to obtain a patient- and treatment-specific CT scan, it is possible to create a 3D model for SHTP.
为浅表热疗计划（SHTP）制定患者和治疗特异性计算机断层扫描（CT）并创建三维（3D）患者模型。
患者、材料和方法：纳入了因复发性乳腺腺癌在既往照射区域接受放疗（RT）和热疗（HT）治疗并知情同意的患者。在治疗区域插入测温导管后，在治疗位置进行 CT 扫描。
迄今为止，共有 26 名患者被纳入研究。在研究期间，对该程序进行了五种类型的调整：（1）用不透射线标记物标记 RT 场，（2）在第一次 HT 治疗后而不是之前进行 CT 扫描，（3）使用充气和泡沫填充（假）水囊，（4）需要不透射线标记物的情况下，将导管更换为不透明导管，（5）如有必要，用不透射线标记物标记可见/可触及的肿瘤范围。通过这些调整，所有必要的信息都可以在 CT 扫描上看到。每个 CT 切片都自动分割为肌肉、脂肪、骨骼和空气。使用分割程序 iSeg 手动勾勒出 RT 场、导管、施源器和肿瘤病变（如果有指示）。然后将模型导入 3D 电磁场模拟器 SEMCAD X。
使用最终程序获取患者和治疗特异性 CT 扫描，可以为 SHTP 创建 3D 模型。
