Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
Clin Toxicol (Phila). 2010 Aug;48(7):737-44. doi: 10.3109/15563650.2010.507548.
Fipronil is a broad-spectrum phenylpyrazole insecticide widely used to control residential pests and is also commonly used for flea and tick treatment on pets. It is a relatively new insecticide and few human toxicity data exist on fipronil.
This paper describes the magnitude and characteristics of acute illnesses associated with fipronil exposure.
Illness cases associated with exposure to fipronil-containing products from 2001 to 2007 were identified from the Sentinel Event Notification System for Occupational Risks (SENSOR)-Pesticides Program and the California Department of Pesticide Regulation.
A total of 103 cases were identified in 11 states. Annual case counts increased from 5 in 2001 to 30 in 2007. Of the cases, 55% were female, the median age was 37 years, and 11% were <15 years old. The majority (76%) had exposure in a private residence, 37% involved the use of pet-care products, and 26% had work-related exposures. Most cases (89%) had mild, temporary health effects. Neurological symptoms (50%) such as headache, dizziness, and paresthesia were the most common, followed by ocular (44%), gastrointestinal (28%), respiratory (27%), and dermal (21%) symptoms/signs. Exposures usually occurred from inadvertent spray/splash/spill of products or inadequate ventilation of the treated area before re-entry.
Our findings indicate that exposure to fipronil can pose a risk for mild, temporary health effects in various body systems. Precautionary actions should be reinforced to prevent fipronil exposure to product users.
氟虫腈是一种广泛使用的苯并吡唑类杀虫剂，用于防治家庭害虫，也常用于宠物的跳蚤和蜱虫防治。它是一种相对较新的杀虫剂，关于氟虫腈的人类毒性数据较少。
本文描述了 2001 年至 2007 年期间与氟虫腈暴露相关的急性疾病的严重程度和特征。
从职业风险监测系统（SENSOR）-农药计划和加利福尼亚农药监管局中确定了与 2001 年至 2007 年期间接触含氟虫腈产品相关的疾病病例。
在 11 个州共发现 103 例病例。每年的病例数从 2001 年的 5 例增加到 2007 年的 30 例。这些病例中，55%为女性，中位年龄为 37 岁，11%的年龄<15 岁。大多数病例（76%）发生在私人住宅，37%涉及宠物护理产品的使用，26%有工作相关的暴露。大多数病例（89%）的健康影响轻微且为暂时性。最常见的是神经症状（50%），如头痛、头晕和感觉异常，其次是眼部（44%）、胃肠道（28%）、呼吸道（27%）和皮肤（21%）症状/体征。暴露通常是由于产品的意外喷雾/飞溅/溢出或在重新进入之前对处理区域通风不足所致。
我们的研究结果表明，接触氟虫腈可能会对人体各个系统造成轻度、暂时的健康影响。应加强预防措施，防止产品使用者接触氟虫腈。
