该研究调节了氟虫腈诱导的雄性白化大鼠的神经毒性。
The modulates the neurotoxicity induced by fipronil in male albino rats.
机构信息
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
出版信息
Biosci Rep. 2019 Mar 1;39(3). doi: 10.1042/BSR20181363. Print 2019 Mar 29.
The extensive use of fipronil (FPN) may trigger hazards to more than insects. The present investigation was carried out to evaluate the abrogating role of (TL) methanol extract (TLE) against the neurotoxic effects provoked by FPN. Fourty male albino rats were assigned into four equal groups. The first group served as control, the second one was orally administered FPN (10.5 mg/kg BW), the third group was given combination of FPN and TLE) (100 mg/kg BW), and the fourth one was orally given TLE. Our findings highlighted the efficacy of TLE as a neuroprotectant through a significant reduction in malondialdehyde (MDA) content by 25.8%, elevations of the reduced glutathione (GSH) level, catalase (CAT,) and superoxide dismutase (SOD) activities by 30.9, 41.2, and 48.2% respectively. Consequently, the relative mRNA levels of both Bax and caspase-3 were down-regulated by 40.54% and caspase-3 by 30.35% compared with the control group. Moreover, restoration of the pathological tissue injuries were detected. In conclusion, TLE proved to be a potent neuroprotective agent against the FPN-induced toxicity.
氟虫腈（FPN）的广泛使用可能会引发对非昆虫生物的危害。本研究旨在评估（TL）甲醇提取物（TLE）对 FPN 引起的神经毒性的缓解作用。将 40 只雄性白化大鼠随机分为 4 组，每组 10 只。第一组作为对照组，第二组给予 FPN（10.5mg/kg BW），第三组给予 FPN 和 TLE 混合物（100mg/kg BW），第四组给予 TLE。我们的研究结果强调了 TLE 作为神经保护剂的功效，通过将丙二醛（MDA）含量降低 25.8%，还原型谷胱甘肽（GSH）水平、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性分别升高 30.9%、41.2%和 48.2%，显著降低了 MDA 含量。此外，Bax 和 caspase-3 的相对 mRNA 水平分别下调了 40.54%和 30.35%。此外，还检测到对组织损伤的恢复。总之，TLE 被证明是一种有效的对抗 FPN 诱导毒性的神经保护剂。
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