华氏巨球蛋白血症中的多发性神经病。M成分在髓鞘上的沉积。
Polyneuropathy in Waldenström's macroglobulinemia. Deposition of M component on myelin sheaths.
作者信息
Julien J, Vital C, Vallat J M, Lagueny A, Deminiere C, Darriet D
出版信息
Arch Neurol. 1978 Jul;35(7):423-5. doi: 10.1001/archneur.1978.00500310025005.
Abstract
A chronic sensory neuropathy was the initial symptom in a case of Waldenström's macroglobulinemia in a 53-year-old woman. Ultrastructural analysis of a biopsied peripheral nerve revealed a modification of the lamellar structure of the myelin sheath. Immunofluorescent microscopy showed IgM-positive deposits on the myelin sheath. The monoclonal globulin (M component) present in the myelin appears to be a causative factor in the neuropathy.
摘要
一名53岁女性的华氏巨球蛋白血症病例中，慢性感觉神经病变是其初始症状。对活检的外周神经进行超微结构分析显示，髓鞘的板层结构发生改变。免疫荧光显微镜检查显示髓鞘上有IgM阳性沉积物。髓鞘中存在的单克隆球蛋白（M成分）似乎是神经病变的致病因素。
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