浆细胞样树突状细胞功能和发育的分子机制。
Molecular mechanisms for plasmacytoid dendritic cell function and development.
机构信息
Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
出版信息
Vaccine. 2010 Nov 23;28(50):8046-7. doi: 10.1016/j.vaccine.2010.09.025. Epub 2010 Sep 17.
Abstract
Dendritic cells (DCs) are activated by immune adjuvants in a DC subset-specific manner. Plasmacytoid DC (pDC) is a unique subset that senses nucleic acid immune adjuvants only through two Toll-like receptors (TLRs), TLR7 and TLR9 and produces large amounts of type I interferons. Here I review recent trend in pDC function and development.
摘要
树突状细胞 (DCs) 通过免疫佐剂以树突状细胞亚群特异性的方式被激活。浆细胞样树突状细胞 (pDC) 是一种独特的亚群，仅通过两种 Toll 样受体 (TLRs)，TLR7 和 TLR9 感知核酸免疫佐剂，并产生大量的 I 型干扰素。在这里，我回顾了 pDC 功能和发展的最新趋势。
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