Department of Medical Laboratory Technology, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Hum Immunol. 2010 Dec;71(12):1243-50. doi: 10.1016/j.humimm.2010.09.007. Epub 2010 Sep 16.
Therapeutic antibodies are widely used in the treatment of various diseases and disease conditions, including cardiovascular diseases, autoimmune disorders, malignancies, and infections. With at least 23 therapeutic agents currently in clinical use and a successful business generating large revenues, major technological advances are now in place to improve the specificity and efficacy of those antibodies already in the market and also generate new, safe and effective macromolecules for the treatment of other ailments. This review provides a summary of the current state of antibody therapy, highlights and discusses recent developments in the field of antibody-based therapeutics production, combination therapy and shows the status of some of the agents that are in clinical trial.
治疗性抗体被广泛应用于各种疾病和病症的治疗，包括心血管疾病、自身免疫性疾病、恶性肿瘤和感染。目前至少有 23 种治疗药物在临床使用，一个成功的业务产生了巨大的收入，重大技术进步已经到位，以提高那些已经在市场上的抗体的特异性和疗效，并产生新的、安全和有效的治疗其他疾病的大分子药物。本综述概述了抗体治疗的现状，强调并讨论了抗体治疗生产、联合治疗领域的最新进展，并展示了一些处于临床试验阶段的药物的现状。
