de Decker S, Bovy C, Deflandre J, Moonen M, Van Nes M-C
Service de gériatrie, centre hospitalier régional de Citadelle, boulevard de 12e de ligne 1, 4000 Liège, Belgium.
Gastroenterol Clin Biol. 2010 Nov;34(11):625-8. doi: 10.1016/j.gcb.2010.08.001. Epub 2010 Sep 17.
We report the case of a patient diagnosed with a villous adenoma of the duodenum showing high degree dysplasia who developed a nephrotic syndrome (NS) due to a membranous nephropathy (MN), demonstrated by renal biopsy. Only the endoscopic resection of the duodenal adenoma could control the NS. The first manifestation of a MN is often the development of a NS. Up to 20% of patients older than 65 years who develop a MN have cancer. Tumours most often identified are those of lung, prostate and digestive tract. A renal biopsy is required to identify this type of nephropathy. If a diagnosis of MN is made, an associated tumour should be looked for.
我们报告了一例十二指肠绒毛状腺瘤伴高度不典型增生的患者，该患者因膜性肾病（MN）并发肾病综合征（NS），肾活检证实了这一点。只有十二指肠腺瘤的内镜切除才能控制NS。MN的首发表现通常是NS的发生。65岁以上发生MN的患者中，高达20%患有癌症。最常发现的肿瘤是肺癌、前列腺癌和消化道肿瘤。需要进行肾活检来确诊这种类型的肾病。如果诊断为MN，应寻找相关肿瘤。
