Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Clin Immunol. 2010 Dec;137(3):322-9. doi: 10.1016/j.clim.2010.08.006. Epub 2010 Sep 17.
B cell tolerance is regulated by receptors that modulate B cell receptor signaling, such as Fc gamma receptor IIb (FcγRIIb; CD32b) and complement receptors (CR) 1 and 2. Deficiency in these receptors may contribute to autoimmunity. To address this we have investigated the receptor expression in healthy individuals in comparison with rheumatoid arthritis (RA) patients. In healthy subjects we found that women had overall lower FcγRIIb expression on B cells than men that significantly decreased with age. RA patients had fewer FcγRIIb, CR1 and CR2 positive B cells and decreased receptor expressions compared to healthy subjects. Further, the RA B cells displayed a significantly increased proliferative response when cultured with interleukin-2 in vitro. In summary, the dysregulated B cells in RA are associated with lower FcγRIIb, CR1 and CR2 levels. The reduced FcγRIIb expression on B cells in women may influence the increased frequency of autoimmunity in women.
B 细胞耐受受调节 B 细胞受体信号的受体调节，如 Fc 受体 IIb（FcγRIIb；CD32b）和补体受体（CR）1 和 2。这些受体的缺乏可能导致自身免疫。为了解决这个问题，我们研究了健康个体与类风湿关节炎（RA）患者的受体表达。在健康受试者中，我们发现女性 B 细胞上的 FcγRIIb 表达总体低于男性，且随年龄增长而显著下降。与健康受试者相比，RA 患者的 FcγRIIb、CR1 和 CR2 阳性 B 细胞数量较少，受体表达水平降低。此外，RA B 细胞在体外与白细胞介素 2 共培养时显示出明显增加的增殖反应。总之，RA 中失调的 B 细胞与 FcγRIIb、CR1 和 CR2 水平降低有关。女性 B 细胞上 FcγRIIb 表达的减少可能会影响女性自身免疫的增加频率。
