Mogg T D, Pollitt C C, Willmore J P, Thompson H
Department of Companion Animal Medicine and Surgery, University of Queensland.
Aust Vet J. 1990 Nov;67(11):399-401. doi: 10.1111/j.1751-0813.1990.tb03026.x.
Three groups of horses and ponies (N = 13, 13 and 12) were treated with ivermectin paste (0.2 mg/kg p.o.), avermectin B1 solution (0.2 mg/kg p.o.), or fenbendazole suspension (10 mg/kg via nasogastric tube). The avermectin B1 was a 1% solution in a propylene glycolglycerol formal base. Faecal strongyle egg counts were performed before, and 14, 28, 42, 56 and 70 d, after treatment. Full-thickness skin biopsies from the neck, pectoral and umbilical regions were examined for Onchocera microfilaria before treatment, and again 14 and 70 d later. Ivermectin therapy produced a significant (P less than 0.01) decrease in mean strongyle egg counts 14, 28, 42 and 56 d after treatment. Avermectin B1 therapy resulted in significant (P less than 0.01) decreases in mean strongyle egg counts 14, 28 and 42 d after treatment. All horses given ivermectin or avermectin B1 had zero strongyle egg counts 14 and 28 d after treatment. Fenbendazole failed to significantly decrease strongyle egg counts. Both ivermectin and avermectin B1 resulted in zero microfilaria counts in all horses 14 d after treatment. On day 70 the percentage decrease in microfilaria counts were 100% and 99.6% respectively. Fenbendazole failed to significantly decrease microfilaria counts. The oral administration of this formulation of avermectin B1 appeared to be highly efficacious against intestinal strongyles and Onchocera microfilaria. The duration of anti-strongyle activity was, however, significantly (P less than 0.01) shorter than that of ivermectin paste.
三组马和小马（数量分别为13匹、13匹和12匹）分别接受伊维菌素糊剂（口服0.2毫克/千克）、阿维菌素B1溶液（口服0.2毫克/千克）或芬苯达唑混悬液（通过鼻胃管给药10毫克/千克）治疗。阿维菌素B1是在丙二醇 - 甘油甲醛基质中的1%溶液。在治疗前以及治疗后14、28、42、56和70天进行粪便圆线虫卵计数。在治疗前以及治疗后14天和70天，对颈部、胸部和脐部区域进行全层皮肤活检，检查盘尾丝虫微丝蚴。伊维菌素治疗在治疗后14、28、42和56天使平均圆线虫卵计数显著（P<0.01）下降。阿维菌素B1治疗在治疗后14、28和42天使平均圆线虫卵计数显著（P<0.01）下降。所有接受伊维菌素或阿维菌素B1治疗的马在治疗后14天和28天圆线虫卵计数为零。芬苯达唑未能显著降低圆线虫卵计数。伊维菌素和阿维菌素B1在治疗后14天使所有马的微丝蚴计数均为零。在第70天，微丝蚴计数的下降百分比分别为100%和99.6%。芬苯达唑未能显著降低微丝蚴计数。口服这种剂型的阿维菌素B1似乎对肠道圆线虫和盘尾丝虫微丝蚴高度有效。然而，其抗圆线虫活性的持续时间显著（P<0.01）短于伊维菌素糊剂。
