Department of Pediatric Infectious Diseases, Clinical Research Center, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Eur J Pediatr. 2011 Mar;170(3):347-50. doi: 10.1007/s00431-010-1297-1. Epub 2010 Sep 18.
Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency of renal scars (Kavukçu et al., BJU Int 83(9):1055-1059, 1999). The aim of this study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2-144), with first-time pyelonephritis verified by an uptake defect on acute dimercaptosuccinic acid (DMSA) scan were included in the study and randomly allocated to the case or control groups. All were given intravenous ceftriaxone for 10 days followed by oral cephalexin for 3 months. Cases in addition were given a single intramuscular dose of vitamin A, 25,000 U for infants below 1 year of age and 50,000 U for older children. At the repeat DMSA scan after 3 months, five of 25 cases (20%) and 17 of 25 controls (68%) had abnormal findings (p = 0.001). In conclusion, administration of vitamin A was associated with a significantly lower rate of permanent renal damage.
动物研究表明，给患有实验性尿路感染的大鼠施用维生素 A 可降低肾瘢痕的频率（Kavukçu 等人，BJU Int 83(9):1055-1059, 1999）。本研究旨在确定维生素 A 对急性肾盂肾炎儿童永久性肾损伤发生率的影响。50 名儿童（中位数年龄为 24 个月[范围为 2-144]），首次通过急性二巯丁二酸摄取缺陷证实患有肾盂肾炎，被纳入研究并随机分配到病例组或对照组。所有儿童均接受 10 天静脉注射头孢曲松，然后口服头孢氨苄 3 个月。此外，病例组额外给予单剂量肌内注射维生素 A，1 岁以下婴儿给予 25,000 U，较大儿童给予 50,000 U。3 个月后重复 DMSA 扫描时，25 例病例中有 5 例（20%）和 25 例对照中有 17 例（68%）出现异常发现（p=0.001）。总之，给予维生素 A 与永久性肾损伤发生率显著降低相关。
