儿童维生素D与尿路感染之间的关联。
Association between vitamin D and urinary tract infection in children.
作者信息
Mahyar Abolfazl, Ayazi Parviz, Safari Sara, Dalirani Reza, Javadi Amir, Esmaeily Shiva
机构信息
Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Mofid Children Hospital, Pediatric Nephrology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Korean J Pediatr. 2018 Mar;61(3):90-94. doi: 10.3345/kjp.2018.61.3.90. Epub 2018 Mar 19.
PURPOSE
The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.
METHODS
In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups.
RESULTS
Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (=0.39). The mean±standard deviation of age in the case and control groups were 53.2±35.6 and 36.1±60.2 months, respectively (=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.4±8.6 ng/mL vs. 16.9±7.4 ng/mL, =0.01).
CONCLUSION
This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.
目的
本研究旨在确定儿童血清25-羟维生素D（25(OH)D）水平与尿路感染（UTIs）之间的关系。
方法
在这项病例对照研究中，比较了70例尿路感染患儿（病例组）和70例健康儿童（对照组）的血清25(OH)D水平。患儿年龄在1个月至12岁之间。采用酶联免疫吸附测定（ELISA）法检测血清25(OH)D水平。对两组结果进行分析和比较。
结果
70例尿路感染患儿（病例组）中，男性5例（7.2%），女性65例（92.8%）。健康儿童（对照组）中，男性9例（12.8%），女性61例（87.2%）（P=0.39）。病例组和对照组的平均年龄±标准差分别为53.2±35.6个月和36.1±60.2个月（P=0.24）。病例组血清25(OH)D的平均水平显著高于对照组（20.4±8.6 ng/mL对16.9±7.4 ng/mL，P=0.01）。
结论
本研究表明儿童血清25(OH)D水平与尿路感染之间存在关联。25(OH)D似乎在尿路感染的发病机制中起作用。
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