Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Ann Surg Oncol. 2010 Oct;17 Suppl 3:338-42. doi: 10.1245/s10434-010-1254-2. Epub 2010 Sep 19.
Pure tubular carcinoma of the breast is a rare subtype with a low incidence of axillary lymph node metastases. The aim of this study was to determine the frequency of axillary lymph node metastasis in patients with pure tubular carcinoma.
We identified patients diagnosed with tubular carcinoma from 1987 to 2009 from our institution's tumor registry. Pathology slides were reviewed, and pure tubular carcinoma was defined as ≥ 90% tubule formation, low nuclear grade, and rare to no mitoses. Medical records were reviewed for clinicopathologic data including tumor size, number of positive and negative axillary lymph nodes, treatment, and recurrence.
We identified 105 cases of pure tubular carcinoma of the breast in 103 patients. Median tumor size was 0.8 (range 0.1-1.8) cm. Nodal staging was performed in 93 cases (89%). Five patients (5.4%) had positive lymph nodes, and two patients (2.2%) had isolated tumor cells. All patients with lymph node metastases had tumors >0.8 cm in size. At 5.2 years' follow-up, no patients have developed recurrence or metastases, or have died from breast cancer.
Axillary lymph node metastases are not common in small pure tubular carcinomas. Nodal staging may be omitted in small pure tubular carcinomas.
乳腺单纯管状癌是一种罕见的亚型，腋窝淋巴结转移的发生率较低。本研究旨在确定单纯管状癌患者腋窝淋巴结转移的频率。
我们从我们机构的肿瘤登记处确定了 1987 年至 2009 年诊断为管状癌的患者。对病理切片进行了复查，将单纯管状癌定义为≥90%的小管形成、低核级和罕见或无有丝分裂。回顾了包括肿瘤大小、阳性和阴性腋窝淋巴结数量、治疗和复发在内的临床病理数据的病历。
我们在 103 例患者中确定了 105 例乳腺单纯管状癌。肿瘤大小中位数为 0.8cm（范围 0.1-1.8cm）。93 例（89%）进行了淋巴结分期。5 例（5.4%）患者淋巴结阳性，2 例（2.2%）患者有孤立肿瘤细胞。所有淋巴结转移患者的肿瘤均大于 0.8cm。在 5.2 年的随访中，没有患者出现复发或转移，也没有死于乳腺癌。
在小的单纯管状癌中，腋窝淋巴结转移并不常见。在小的单纯管状癌中可以省略淋巴结分期。
