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鉴定小鼠乳腺干细胞的功能特性。

Functional characterization of stem cell activity in the mouse mammary gland.

机构信息

Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.

出版信息

Stem Cell Rev Rep. 2011 Jun;7(2):238-47. doi: 10.1007/s12015-010-9191-9.

DOI:10.1007/s12015-010-9191-9
PMID:20853073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3492888/
Abstract

Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.

摘要

小鼠乳腺的任何部分都能够在移植到受体宿主的上皮去分化乳腺脂肪垫后，重现克隆来源的完整和功能正常的乳腺树。因此，它是研究体干细胞功能的理想模型组织。本综述将概述已知的关于小鼠乳腺中的干细胞/祖细胞功能，包括祖细胞群体如何能够在功能上被定义，选择性 DNA 链分离的证据和潜在作用，以及生态位在维持和控制干细胞功能中的作用。

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2
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.肠上皮干细胞隔室中的纺锤体取向偏向在癌前组织中丢失。
Cell Stem Cell. 2010 Feb 5;6(2):175-81. doi: 10.1016/j.stem.2009.12.007.
3
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.
组织特异性微环境：组织工程和再生医学的关键工具。
J Biol Eng. 2017 Nov 16;11:34. doi: 10.1186/s13036-017-0077-0. eCollection 2017.
4
Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.乳腺细胞外基质指导睾丸和胚胎干细胞的分化，使其在体内形成功能性乳腺。
Sci Rep. 2017 Jan 10;7:40196. doi: 10.1038/srep40196.
5
Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis.通过莱昂假说进行乳腺上皮细胞谱系分析。
Int J Stem Cell Res Ther. 2016;3(1). doi: 10.23937/2469-570x/1410018. Epub 2016 Jan 3.
6
The dynamics of murine mammary stem/progenitor cells.小鼠乳腺干细胞/祖细胞的动力学
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