鉴定小鼠乳腺干细胞的功能特性。
Functional characterization of stem cell activity in the mouse mammary gland.
机构信息
Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.
出版信息
Stem Cell Rev Rep. 2011 Jun;7(2):238-47. doi: 10.1007/s12015-010-9191-9.
Abstract
Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.
摘要
小鼠乳腺的任何部分都能够在移植到受体宿主的上皮去分化乳腺脂肪垫后，重现克隆来源的完整和功能正常的乳腺树。因此，它是研究体干细胞功能的理想模型组织。本综述将概述已知的关于小鼠乳腺中的干细胞/祖细胞功能，包括祖细胞群体如何能够在功能上被定义，选择性 DNA 链分离的证据和潜在作用，以及生态位在维持和控制干细胞功能中的作用。
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