法国酒精性肝硬化患者Ⅰ类酒精脱氢酶基因多态性的基因分型研究。法国酒精与肝脏研究小组。
Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcoholic cirrhosis. The French Group for Research on Alcohol and Liver.
作者信息
Couzigou P, Fleury B, Groppi A, Cassaigne A, Begueret J, Iron A
机构信息
Department of Hepatogastroenterology, Haut-Lévêque Hospital, Pessac, France.
出版信息
Alcohol Alcohol. 1990;25(6):623-6. doi: 10.1093/oxfordjournals.alcalc.a045058.
Comparison of alcohol dehydrogenase polymorphism at the loci ADH2 and ADH3 is made in France between 46 alcoholic cirrhotic patients and 39 controls, by genotyping technique using polymerase chain reaction on blood microsample collected on blotting paper. The genotype distributions are similar, with low frequency of the ADH2(2) allele. Polymorphism at the ADH3 locus is not a genetic factor for alcoholic cirrhosis in France.
在法国，通过使用聚合酶链反应对采集于吸水纸上的血液微量样本进行基因分型技术，对46名酒精性肝硬化患者和39名对照者的ADH2和ADH3基因座上的酒精脱氢酶多态性进行了比较。基因型分布相似，ADH2(2)等位基因频率较低。在法国，ADH3基因座的多态性不是酒精性肝硬化的遗传因素。
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