Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Neurosci Lett. 2010 Dec 3;486(1):38-42. doi: 10.1016/j.neulet.2010.09.040. Epub 2010 Sep 18.
Exendin-4 isolated from Heloderma suspectum venom acts via glucagon-like peptide 1 (GLP-1) receptor and has clinically been used in the type 2 diabetes. In this study, we investigated the effects of exendin-4 on cell proliferation and neuroblast differentiation in the subgranular zone (SGZ) of the dentate gyrus in mice. Exendin-4 was treated intraperitoneally to male ICR mice twice a day for 21 days. The exendin-4-treated group showed a significantly higher number of Ki67- (1.51-fold), doublecortin (DCX)- (2.5-fold) and 5-bromo-2'-deoxyuridine (BrdU)+DCX- (2.46-fold) immunoreactive cells in the SGZ of the dentate gyrus compared to the control group. The results of this study showed that treatment with exendin-4 increased cell proliferation neuroblast differentiation in the SGZ of the dentate gyrus, suggesting that exendin-4 promotes structural plasticity in the dentate gyrus.
从 Heloderma suspectum 毒液中分离出的 Exendin-4 通过胰高血糖素样肽 1 (GLP-1) 受体发挥作用，临床上已用于 2 型糖尿病。在这项研究中，我们研究了 Exendin-4 对小鼠齿状回颗粒下区 (SGZ) 中细胞增殖和神经母细胞分化的影响。Exendin-4 通过腹腔内给药，每天两次处理雄性 ICR 小鼠 21 天。与对照组相比，Exendin-4 处理组的 Ki67-（1.51 倍）、双皮质素 (DCX)-（2.5 倍）和 5-溴-2'-脱氧尿苷 (BrdU)+DCX-（2.46 倍）免疫反应性细胞在齿状回的 SGZ 中明显增加。这项研究的结果表明，Exendin-4 的治疗增加了齿状回 SGZ 中的细胞增殖和神经母细胞分化，表明 Exendin-4 促进了齿状回的结构可塑性。
