Horn Pamela L, Wrona Sharon, Beebe Allan C, Klamar Jan E
Nationwide Children's Hospital, Columbus, OH, USA.
Orthop Nurs. 2010 Sep-Oct;29(5):342-3. doi: 10.1097/NOR.0b013e3181edd876.
There are studies and literature that support the claim that ketorolac use after spinal fusion in the adult population can increase the risk of pseudarthrosis, instrumentation failure, and/or nonunion. There is limited research when using ketorolac in the pediatric population, especially short-term use.
Chart review of 46 pediatric patients who had prior spinal fusions for scoliosis between July 2003 and August 2005. Twenty-five of the patients received ketorolac and 21 did not. The lengths of stay, incidence of curve progression, and/or incidence of nonunion or instrumentation failure were compared in the 2 groups.
At the 1-year follow-up, 95% of the patients returned and at the 3-year follow-up, 52% of the patients returned and there was no clinical or radiographic evidence of curve progression, nonunion, or instrumentation failure.
This is a retrospective study looking at results of 2 patient groups. This is a level III study.
有研究和文献支持这样的观点，即在成年人群中脊柱融合术后使用酮咯酸会增加假关节形成、内固定失败和/或骨不连的风险。在儿科人群中使用酮咯酸的研究有限，尤其是短期使用。
回顾性分析2003年7月至2005年8月期间46例因脊柱侧弯接受过脊柱融合术的儿科患者的病历。其中25例患者使用了酮咯酸，21例未使用。比较两组患者的住院时间、侧弯进展发生率和/或骨不连或内固定失败发生率。
在1年随访时，95%的患者复诊；在3年随访时，52%的患者复诊，且没有临床或影像学证据表明存在侧弯进展、骨不连或内固定失败。
这是一项回顾性研究，观察了两组患者的结果。这是一项III级研究。
