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[鸟类个体发育过程中内分泌腺蛋白质合成及酶活性的变化]

[Change in protein synthesis and enzyme activity in avian endocrine glands during ontogenesis].

作者信息

Khozhiakhmedov G

出版信息

Biokhimiia. 1990 Nov;55(11):1984-8.

PMID:2085616
Abstract

The synthesis of cytoplasmic proteins and the activity of cAMP-dependent protein kinase were studied in the thyroid gland and thymus of intact and irradiated (0.05 Gr) embryos and chicks. The increase in labeled amino acid incorporation into proteins of irradiated chicken endocrine organs during postnatal development was more apparent in thyrocytes. Stimulation of protein kinase activity in the thyroid gland and thymus was observed at the same periods of time. It was supposed that minor doses of ionizing radiation stimulate synthetic processes as well as phosphorylation of proteins responsible for differentiation of avian endocrine organs.

摘要

研究了完整和受辐照(0.05戈瑞)胚胎及雏鸡的甲状腺和胸腺中细胞质蛋白的合成以及环磷酸腺苷(cAMP)依赖性蛋白激酶的活性。在出生后发育过程中,受辐照鸡内分泌器官蛋白质中标记氨基酸掺入量的增加在甲状腺细胞中更为明显。在相同时间段观察到甲状腺和胸腺中蛋白激酶活性的刺激。据推测,小剂量电离辐射刺激了禽类内分泌器官分化相关蛋白的合成过程以及磷酸化。

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1
[Change in protein synthesis and enzyme activity in avian endocrine glands during ontogenesis].[鸟类个体发育过程中内分泌腺蛋白质合成及酶活性的变化]
Biokhimiia. 1990 Nov;55(11):1984-8.
2
[The effect of a low dose of ionizing radiation and of gangliosides on the adenylate cyclase activity of the chicken thymus and thyroid in ontogeny].[低剂量电离辐射和神经节苷脂对鸡胚胎期胸腺和甲状腺腺苷酸环化酶活性的影响]
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[The effect of a low dose of ionizing radiation on the activity of cAMP-dependent phosphodiesterase and protein kinase of chicken thymus in ontogenesis].
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[The effect of small doses of ionizing radiation on the cAMP system in the thyroid gland of chick embryos].
Radiobiologiia. 1986 Jul-Aug;26(4):514-6.
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[Change in the protein metabolism in the glands of internal secretion and in several other organs of irradiated rats].[受辐射大鼠内分泌腺及其他一些器官中蛋白质代谢的变化]
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[The spectra of de novo synthesized proteins in the early stages of radiation death of lymphocytes in the rat thymus].[大鼠胸腺淋巴细胞辐射死亡早期阶段新生合成蛋白质的光谱]
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[Effect of small doses of ionizing radiation on thyroid gland cells during embryogenesis].[胚胎发育过程中小剂量电离辐射对甲状腺细胞的影响]
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