Zhivotovskiĭ B D, Puchkova L V, Denezhkina V V, Gaĭtskhoki V S, Khanson K P
Radiobiologiia. 1988 Nov-Dec;28(6):737-44.
A comparative study was made of the spectrum of thymus cell proteins in the control and gamma-irradiated rats. It was shown that early after irradiation a group of proteins appeared in rat thymus cells which had not been traced, or detected in much lower amounts, in intact cells. Part of those polypeptides were referred to general stressor proteins, the other were specific for the effect of ionizing radiation. The spectrum of de novo synthesized enzymes changed with time after irradiation. Some of the proteins were found to induce chromatin degradation in the control cells and, presumably, to be involved in the implementation of the programmed cell death.
对对照大鼠和γ射线辐照大鼠的胸腺细胞蛋白质谱进行了比较研究。结果表明，辐照后早期，大鼠胸腺细胞中出现了一组蛋白质，这些蛋白质在完整细胞中未被检测到，或含量极低。其中部分多肽被归类为一般应激蛋白，其他则是电离辐射效应所特有的。辐照后，新生合成酶的谱随时间发生变化。发现一些蛋白质可诱导对照细胞中的染色质降解，并且可能参与程序性细胞死亡的执行。
