针对螺旋-受体相互作用的小分子抑制剂分析：Bcl-2 家族抑制剂 BH3I-1 能有效抑制 p53/hDM2。
Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.
机构信息
Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Blvd, Tucson, AZ 85721, USA.
出版信息
Chem Commun (Camb). 2010 Nov 14;46(42):8020-2. doi: 10.1039/c0cc02969f. Epub 2010 Sep 20.
Abstract
We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.
摘要
我们验证了一种用于快速分析蛋白质-蛋白质相互作用小分子抑制剂的实用方法。我们发现一种众所周知的 BH3 家族抑制剂可以有效地抑制 p53/hDM2 相互作用。
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