Department of Neurology, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel.
J Neurol. 2010 Dec;257(12):1963-9. doi: 10.1007/s00415-010-5743-9. Epub 2010 Sep 21.
The spectrum of post infectious (PI) central nervous system (CNS) conditions includes a range of grey and white-matter disorders which can occur after viral or bacterial infections or in response to vaccinations. The clinical, radiological and immunological phenomenology raises a number of issues regarding the nature of immune-mediated CNS abnormalities, their etiology, pathogenesis and therapy. Here we focus on crucial issues pertaining to pathogenesis and aim to identify where current knowledge is insufficient in order to suggest future avenues of clinical and experimental research that may help to devise optimal therapy for these conditions.
感染后（PI）中枢神经系统（CNS）疾病谱包括一系列灰质和白质疾病，可发生于病毒或细菌感染后，或对疫苗接种的反应中。临床、影像学和免疫学表现提出了一系列关于免疫介导的 CNS 异常的性质、病因、发病机制和治疗的问题。在这里，我们重点关注发病机制的关键问题，并试图确定当前知识不足的地方，以便提出未来的临床和实验研究途径，这可能有助于为这些疾病制定最佳治疗方案。
