Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Endourol. 2010 Dec;24(12):2033-6. doi: 10.1089/end.2010.0193. Epub 2010 Sep 21.
This study was conducted to examine the efficacy of ketamine along with lidocaine gel for instillation in the male urethra for easiness of outpatient rigid cystoscopy, as compared with only using lidocaine gel.
A total of 60 consecutive men who were scheduled to undergo rigid cystoscopy were randomly assigned to receive either 10 mL of 2% lidocaine gel combined with 2 mL normal saline, or 10 mL of 2% lidocaine gel combined with 2 mL ketamine (100 mg). Hemodynamic changes and the level of pain perception of patients at the beginning, during, and after every procedure in both groups were recorded by using the visual analogue scale.
There were no significant differences in hemodynamic changes between the two groups; however, the perception of pain was significantly decreased when lidocaine was used in conjunction with ketamine, most notably during the first 5 minutes of cystoscopy.
Instillation of lidocaine gel in conjunction with ketamine in the urethra could decrease pain perception and make men undergoing outpatient rigid cystoscopy more comfortable during the procedure.
本研究旨在考察在男性尿道中注入氯胺酮与利多卡因凝胶以减轻门诊硬性膀胱镜检查的难度，并与仅使用利多卡因凝胶进行比较。
共有 60 名连续男性患者被随机分配接受 10 mL 2%利多卡因凝胶联合 2 mL 生理盐水，或 10 mL 2%利多卡因凝胶联合 2 mL 氯胺酮（100 mg）。通过视觉模拟量表记录两组患者在每个操作过程开始、期间和结束时的血流动力学变化和疼痛感知水平。
两组患者的血流动力学变化无显著差异；然而，当利多卡因与氯胺酮联合使用时，疼痛感知显著降低，尤其是在膀胱镜检查的前 5 分钟。
在尿道中注入利多卡因凝胶联合氯胺酮可以减轻疼痛感知，使接受门诊硬性膀胱镜检查的男性在手术过程中更加舒适。
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