Department of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland.
BMC Infect Dis. 2010 Sep 21;10:277. doi: 10.1186/1471-2334-10-277.
Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children.
A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.
320 Children (out of 1228, 26.1%) complied with all the follow-up assessments. Plasmodium prevalence and mean Plasmodium parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having Plasmodium infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean Plasmodium density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in Plasmodium density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.
Repeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of Plasmodium infection in preschool children which coincided with a reduction in both the prevalence and intensity of A. lumbricoides infections.
Current controlled trials ISRCTN44215995.
寄生虫感染会改变疟疾的易感性。需要研究驱虫方案是否会影响学龄前儿童的疟原虫感染。
进行了一项双盲安慰剂对照随机试验，以调查驱虫治疗对 12-59 个月儿童疟原虫感染的影响。儿童被随机分配每四个月接受阿苯达唑或安慰剂治疗 12 个月，并在 14 个月时进行随访。
320 名儿童（1228 名中的 26.1%）完成了所有随访评估。治疗组的疟原虫患病率和平均疟原虫寄生虫密度明显高于安慰剂组（44.9%和 2319 ± SE 511），而基线时安慰剂组分别为 33.3%和 1471 ± 341。在安慰剂组和治疗组中，儿童疟原虫感染的几率随着时间的推移而增加，但治疗组儿童的感染增加速度明显较慢（P=0.002）。到第 14 个月时，安慰剂组的平均疟原虫密度增加了 156%，治疗组增加了 98%，但两组间疟原虫密度的变化率无显著差异。治疗组儿童血红蛋白的基线变化较安慰剂组增加更为陡峭，但这并不具有统计学意义。
14 个月内重复进行四个月一次的驱虫治疗，可显著降低学龄前儿童疟原虫感染的患病率增加，同时也降低了蛔虫感染的流行率和强度。
当前对照试验 ISRCTN44215995。
