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[抗生素耐药性:迫切需要采取的措施]

[Antibiotic resistance: measures urgently needed].

作者信息

Kluytmans Jan, Vandenbroucke-Grauls Christina, van der Meer Jos W M

机构信息

VU medisch centrum, Amsterdam, afd. Medische Microbiologie en Infectiepreventie, the Netherlands.

出版信息

Ned Tijdschr Geneeskd. 2010;154:A2261.

Abstract

Antimicrobial resistance is increasing rapidly and there are hardly any new antimicrobial agents to be expected in the coming years. The number of patients affected by extended spectrum beta-lactamase producing organisms (ESBLs) is rising and there are strong indications that this is caused in part by the use of antimicrobial agents in animal husbandry. There are many arguments against the widespread use of antimicrobial agents in food-production animals, but this has not resulted in decreased usage so far. The current situation is critical and requires immediate action. In human healthcare the prescription of 'rescue' antibiotics, e.g. carbapenems, has to be restricted and controlled. In animal husbandry the use of antibiotics has to be reduced dramatically and a more sustainable approach to food production has to be supported by government and consumers.

摘要

抗菌药物耐药性正在迅速增加,预计未来几年几乎不会有新的抗菌药物出现。受产超广谱β-内酰胺酶(ESBLs)生物体影响的患者数量正在上升,并且有强有力的迹象表明,这部分是由畜牧业中抗菌药物的使用所导致的。有许多反对在食用动物中广泛使用抗菌药物的理由,但到目前为止,这并没有导致用药量的减少。当前形势危急,需要立即采取行动。在人类医疗保健领域,必须限制和控制“挽救性”抗生素(如碳青霉烯类)的处方。在畜牧业中,必须大幅减少抗生素的使用,政府和消费者必须支持一种更具可持续性的食品生产方式。

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