Sorimachi K, Akimoto K, Yamazaki S, Niwa A, Toda S, Yasumura Y
Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
Cell Struct Funct. 1990 Oct;15(5):317-22. doi: 10.1247/csf.15.317.
When macrophages derived from bone marrow were incubated with lignin derivative at 10 micrograms/ml, they formed multinucleated giant cells containing more than sixty nuclei. Cine-microscopic observation revealed that the formation of the giant cells was due to cell fusion. This phenomenon was specific for primary-cultured macrophages, and was not observed with either a macrophage cell line or established cell lines derived from other tissues.
当来自骨髓的巨噬细胞与浓度为10微克/毫升的木质素衍生物一起孵育时，它们形成了含有60多个细胞核的多核巨细胞。电影显微镜观察显示，巨细胞的形成是由于细胞融合。这种现象对原代培养的巨噬细胞具有特异性，在巨噬细胞系或源自其他组织的已建立细胞系中均未观察到。
