Chen B H
Huazhong University of Science and Technology, Wuhan.
Zhonghua Jie He He Hu Xi Za Zhi. 1990 Oct;13(5):268-70, 316-7.
Penicillamine (P) and tetramethyl-pyrazine (T) were administered to treat experimentally hypoxic pulmonary hypertension in rats exposed to hypoxia of 380 torr for up to 21-days. The results of this study showed: Hypoxia increased RVP, the RV/LV + S ratio, the MT% and the MA%. P and T all prevented the hypoxia-induced increases in RVP, the RV/LV + S ratio, but the effect of T on the pulmonary artery remodeling induced by hypoxia was weaker than that of P. The MT% and the MA% were significantly lower in H/P group than in H group (P less than 0.01, P less than 0.05; respectively). Although the MT% was lower in H/T group than in hypoxia group (P less than 0.05), there was no statistical difference in the MA% between H/T group and H group (P greater than 0.05). The MT% and the MA% were significantly lower in H/PT group than in H group (P less than 0.01, P less than 0.01, respectively), and there was no statistical difference in MA% between H/PT group and N group (P greater than 0.05). It was concluded that P prevented primarily pulmonary artery remodeling induced by hypoxia and T inhibited mainly hypoxic pulmonary vasoconstriction response, so prevented partially hypoxic pulmonary hypertension and right ventricular hypertrophy.
给暴露于380托低氧环境长达21天的大鼠注射青霉胺（P）和川芎嗪（T）以治疗实验性低氧性肺动脉高压。本研究结果显示：低氧增加了右心室压（RVP）、右心室/左心室+室间隔厚度比值（RV/LV + S ratio）、肌型动脉中层厚度百分比（MT%）和肌型动脉面积百分比（MA%）。P和T均能防止低氧诱导的RVP及RV/LV + S比值升高，但T对低氧诱导的肺动脉重塑的作用弱于P。H/P组的MT%和MA%显著低于H组（分别为P < 0.01，P < 0.05）。虽然H/T组的MT%低于低氧组（P < 0.05），但H/T组和H组之间的MA%无统计学差异（P > 0.05）。H/PT组的MT%和MA%显著低于H组（分别为P < 0.01，P < 0.01），且H/PT组和N组之间的MA%无统计学差异（P > 0.05）。结论是，P主要预防低氧诱导的肺动脉重塑，T主要抑制低氧性肺血管收缩反应，从而部分预防低氧性肺动脉高压和右心室肥厚。
