Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand.
Ann Rheum Dis. 2010 Oct;69(10):1738-43. doi: 10.1136/ard.2010.136218.
Major progress has been made in the past decade in understanding the pathogenesis and treatment of gout. These advances include identification of the genetic and environmental risk factors for gout, recognition that gout is an important risk factor for cardiovascular disease, elucidation of the pathways regulating the acute gout attack and the development of novel therapeutic agents to treat both the acute and chronic phases of the disease. This review summarises these advances and highlights the research agenda for the next decade.
在过去的十年中，人们在理解痛风的发病机制和治疗方面取得了重大进展。这些进展包括确定了痛风的遗传和环境风险因素，认识到痛风是心血管疾病的一个重要危险因素，阐明了调节急性痛风发作的途径，并开发了治疗疾病急性和慢性阶段的新型治疗药物。本综述总结了这些进展，并强调了下一个十年的研究议程。
