Crittenden Daria B, Pillinger Michael H
Rheumatology Section, New York Harbor VA Healthcare System New York Campus, New York, New York, USA.
Bull NYU Hosp Jt Dis. 2011;69(3):257-63.
Over the past decade, the pace of investigation in the field of gout has accelerated tremendously. New advances have led to deeper insight into the processes of inflammation and innate immunity, and new treatments are now available, or likely to become available in the near future. Some of the more interesting new findings in the field of gout are presented in the context of gout biology and treatment overall. Gout epidemiology, current understanding of renal urate handling, recent investigations into the mechanism of inflammation in acute gout, dietary factors in gout development, the potential role of hyperuricemia in cardiovascular and renal disease, and treatments that are either newly available or in development are discussed.
在过去十年中,痛风领域的研究步伐大幅加快。新的进展使人们对炎症和固有免疫过程有了更深入的了解,并且现在已有新的治疗方法,或者在不久的将来可能会出现。本文将在痛风生物学和整体治疗的背景下介绍痛风领域一些更有趣的新发现。文中讨论了痛风流行病学、目前对肾脏尿酸处理的认识、近期对急性痛风炎症机制的研究、痛风发展中的饮食因素、高尿酸血症在心血管和肾脏疾病中的潜在作用,以及新出现的或正在研发的治疗方法。