猪门静脉分流术后脂质及脂蛋白分泌情况

Lipid and lipoprotein secretion following portacaval shunt in swine.

作者信息

Nestruck A C, Bergseth M, Bidallier M, Davignon J, Marcel Y L

出版信息

Atherosclerosis. 1978 Mar;29(3):355-62. doi: 10.1016/0021-9150(78)90082-5.

PMID:208587

Abstract

Lipid and lipoprotein secretion were studied over 24 h in normal and portacaval shunted (PCS) fasting miniature swine after an infusion of Triton WR-1339 and [3H]amino acid mixture. The plasma triglyceride secretion rate and the secretion of triglyceride, total cholesterol and protein in the very low density lipoprotein fraction (VLDL) were linear for about 9 h after Triton. No net catabolism of the VLDL appeared to take place over the 24 h. Due to large variation, differences in the absolute secretion rates of plasma triglyceride and of the VLDL constituents could not be shown. However, the secretion of VLDL cholesterol in the PCS group appeared to be lower than that of the sham group when corrected for metabolic body size and plasma volume.

摘要

在给正常和门腔分流（PCS）的禁食小型猪输注 Triton WR - 1339 和 [3H]氨基酸混合物后，对其脂质和脂蛋白分泌进行了 24 小时的研究。注射 Triton 后约 9 小时，血浆甘油三酯分泌率以及极低密度脂蛋白（VLDL）部分中甘油三酯、总胆固醇和蛋白质的分泌呈线性。在 24 小时内似乎没有发生 VLDL 的净分解代谢。由于差异较大，未能显示出血浆甘油三酯和 VLDL 成分绝对分泌率的差异。然而，校正代谢体重和血浆体积后，PCS 组中 VLDL 胆固醇的分泌似乎低于假手术组。