ATP synthase: from sequence to ring size to the P/O ratio.
作者信息
Ferguson Stuart J
机构信息
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
出版信息
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16755-6. doi: 10.1073/pnas.1012260107. Epub 2010 Sep 21.
Abstract
摘要
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本文引用的文献
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2
36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthase.F₀F₁-ATP合酶中质子驱动的c环旋转的36度步长。
EMBO J. 2009 Sep 16;28(18):2689-96. doi: 10.1038/emboj.2009.213. Epub 2009 Jul 30.
3
The c13 ring from a thermoalkaliphilic ATP synthase reveals an extended diameter due to a special structural region.来自嗜热嗜碱ATP合酶的c13环由于一个特殊的结构区域而呈现出扩大的直径。
J Mol Biol. 2009 May 8;388(3):611-8. doi: 10.1016/j.jmb.2009.03.052. Epub 2009 Mar 24.
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The thermodynamic H+/ATP ratios of the H+-ATPsynthases from chloroplasts and Escherichia coli.叶绿体和大肠杆菌中H⁺-ATP合酶的热力学H⁺/ATP比率。
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3745-50. doi: 10.1073/pnas.0708356105. Epub 2008 Mar 3.
5
P/O ratios of mitochondrial oxidative phosphorylation.线粒体氧化磷酸化的磷氧比
Biochim Biophys Acta. 2005 Jan 7;1706(1-2):1-11. doi: 10.1016/j.bbabio.2004.09.004.
6
The A-type ATP synthase subunit K of Methanopyrus kandleri is deduced from its sequence to form a monomeric rotor comprising 13 hairpin domains.嗜热栖热菌的 A 型 ATP 合酶亚基 K 由其序列推导而来，形成一个包含 13 个发夹结构域的单体转子。
FEBS Lett. 2003 May 22;543(1-3):47-50. doi: 10.1016/s0014-5793(03)00398-3.
7
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9
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