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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lennon B W, Kaiser I I

Department of Molecular Biology, University of Wyoming, Laramie 82071.

Comp Biochem Physiol B. 1990;97(4):695-9. doi: 10.1016/0305-0491(90)90109-7.

A crotoxin-like protein was isolated from the venom of a South American rattlesnake Crotalus durissus collilineatus. 2. Many of its properties are similar to those of crotoxin, including its non-covalent heterodimeric structure, electrophoretic mobility on SDS-PAGE, isoelectric focusing properties, toxicity in mice, immunological reactivity, multiple isoforms, phospholipase activity, peptide map, and instability on an anion-exchange column. 3. Results indicate that "collilineatus toxin" is strongly homologous with crotoxin, found in the venom of Crotalus durissus terrificus, and all other characterized rattlesnake neurotoxins.

从南美响尾蛇Crotalus durissus collilineatus的毒液中分离出一种类响尾蛇毒素蛋白。2. 它的许多特性与响尾蛇毒素相似，包括其非共价异二聚体结构、SDS-PAGE上的电泳迁移率、等电聚焦特性、对小鼠的毒性、免疫反应性、多种同工型、磷脂酶活性、肽图以及在阴离子交换柱上的不稳定性。3. 结果表明，“collilineatus毒素”与在Crotalus durissus terrificus毒液中发现的响尾蛇毒素以及所有其他已鉴定的响尾蛇神经毒素具有高度同源性。

Lennon B W, Kaiser I I

Department of Molecular Biology, University of Wyoming, Laramie 82071.

Comp Biochem Physiol B. 1990;97(4):695-9. doi: 10.1016/0305-0491(90)90109-7.

A crotoxin-like protein was isolated from the venom of a South American rattlesnake Crotalus durissus collilineatus. 2. Many of its properties are similar to those of crotoxin, including its non-covalent heterodimeric structure, electrophoretic mobility on SDS-PAGE, isoelectric focusing properties, toxicity in mice, immunological reactivity, multiple isoforms, phospholipase activity, peptide map, and instability on an anion-exchange column. 3. Results indicate that "collilineatus toxin" is strongly homologous with crotoxin, found in the venom of Crotalus durissus terrificus, and all other characterized rattlesnake neurotoxins.

从南美响尾蛇Crotalus durissus collilineatus的毒液中分离出一种类响尾蛇毒素蛋白。2. 它的许多特性与响尾蛇毒素相似，包括其非共价异二聚体结构、SDS-PAGE上的电泳迁移率、等电聚焦特性、对小鼠的毒性、免疫反应性、多种同工型、磷脂酶活性、肽图以及在阴离子交换柱上的不稳定性。3. 结果表明，“collilineatus毒素”与在Crotalus durissus terrificus毒液中发现的响尾蛇毒素以及所有其他已鉴定的响尾蛇神经毒素具有高度同源性。