经囊状动脉内水包油包水乳液中表阿霉素灌注治疗肝细胞癌。
Transcatheter infusion of epirubicin in water-in-oil-in-water emulsion via a cystic artery for the treatment of hepatocellular carcinoma.
机构信息
Department of Radiology, Miyakonojo Medical Association Hospital, 5822-3 Oiwadacho, Miyakonojo 885-0062, Japan.
出版信息
Cardiovasc Intervent Radiol. 2011 Aug;34(4):802-7. doi: 10.1007/s00270-010-9988-6. Epub 2010 Sep 23.
PURPOSE
We have previously reported the clinical efficacy of water-in-oil-in-water (W/O/W) emulsion containing anticancer agent. The purpose of this study was to evaluate the safety and effectiveness of transcatheter arterial infusion (TAI) of W/O/W emulsion via a cystic artery for hepatocellular carcinoma (HCC).
METHODS
TAI of a W/O/W emulsion was performed at our institute in five patients with Stage III or IV HCC with blood supply from the cystic artery. In all patients, 2-12 ml/O/W emulsion was infused via a cystic artery. Therapeutic effects and complications were evaluated in these patients.
RESULTS
Of the five patients treated, one achieved a complete response and two achieved a partial response. After treatment, acute cholecystitis or gallbladder ischemia that required treatment was not encountered in any patient.
CONCLUSIONS
W/O/W emulsion can be safely infused via a cystic artery without major complications; it is a good therapeutic option for the patients with advanced HCC fed by a cystic artery.
目的
我们之前报道过含有抗癌剂的水包油包水（W/O/W）乳液的临床疗效。本研究的目的是评估经囊状动脉给予 W/O/W 乳液行经导管动脉内化疗（TAI）治疗肝细胞癌（HCC）的安全性和有效性。
方法
在我院，对 5 例存在囊状动脉供血的 III 或 IV 期 HCC 患者进行了 W/O/W 乳液的 TAI。所有患者均经囊状动脉给予 2-12ml/O/W 乳液。对这些患者的治疗效果和并发症进行了评估。
结果
5 例治疗患者中，1 例完全缓解，2 例部分缓解。治疗后，未发生需要治疗的急性胆囊炎或胆囊缺血等严重并发症。
结论
W/O/W 乳液可安全经囊状动脉输注，无严重并发症，是囊状动脉供血的晚期 HCC 患者的一种较好的治疗选择。
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