Selvaggi F P, Ditonno P, Traficante A, Battaglia M, Di Lorenzo V
Department of Surgery/Surgical Nephrology, University of Bari, Italy.
Chemotherapy. 1990;36 Suppl 1:31-3. doi: 10.1159/000238813.
The efficacy, tolerability and side effects of a 'single-dose' therapy for acute female lower UTIs in general practice with fosfomycin trometamol (3 g) or norfloxacin (800 mg) were compared in a randomized double-blind study. 89 patients were included in the trial; however, 36 (40.4%) did not present significant bacteriuria and were assessed mainly for tolerability. Of the 53, 28 patients in the fosfomycin trometamol group and 25 patients in the norfloxacin group, 21 (75%) had no bacteriuria at immediate follow-up after treatment with fosfomycin trometamol and 20 (84%) with norfloxacin. The tolerability of both drugs in single dose was absolute.
在一项随机双盲研究中，比较了在普通医疗实践中使用磷霉素氨丁三醇（3克）或诺氟沙星（800毫克）对急性女性下尿路感染进行“单剂量”治疗的疗效、耐受性和副作用。89名患者纳入试验；然而，36名（40.4%）患者没有显著菌尿，主要评估其耐受性。在53名患者中，磷霉素氨丁三醇组28名患者，诺氟沙星组25名患者，磷霉素氨丁三醇治疗后立即随访时，21名（75%）无菌尿，诺氟沙星治疗后20名（84%）无菌尿。两种药物单剂量的耐受性都很好。
