Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
Pediatr Blood Cancer. 2011 Feb;56(2):301-3. doi: 10.1002/pbc.22734.
Acute lymphoblastic leukemia (ALL) can be preceded by a prodromal phase of bone marrow failure. In serial trephine biopsies in a girl with acquired bone marrow hypoplasia, we have identified a monoclonal B-cell precursor population characterized by a clone-specific IgH-FR3 gene rearrangement. Progression to ALL more than 4 months later was accompanied by acquisition of an additional T-cell receptor rearrangement. Thus, hypoplastic pre- and overt leukemia share a common clonal origin. Prospective biobanking and extended molecular analysis can help to better understand the nature and sequence of genetic events during progression of a covert (pre)leukemic clone.
急性淋巴细胞白血病（ALL）可在前骨髓衰竭的前驱期出现。在一患有获得性骨髓发育不良的女孩的连续骨髓穿刺活检中，我们鉴定出一个单克隆 B 细胞前体细胞群，其特征为克隆特异性的 IgH-FR3 基因重排。4 个多月后进展为 ALL 时，伴有另外一个 T 细胞受体重排。因此，发育不良的前驱期和显性白血病具有共同的克隆起源。前瞻性生物样本库和扩展分子分析有助于更好地理解隐匿性（前驱）白血病克隆进展过程中的遗传事件的性质和顺序。
