Souza Renan P, Meltzer Herbert Y, Lieberman Jeffrey A, Le Foll Bernard, Kennedy James L
Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Hum Psychopharmacol. 2010 Nov;25(7-8):582-5. doi: 10.1002/hup.1146. Epub 2010 Sep 22.
Schizophrenia patients show alterations in the synaptic connectivity. However, it remains unknown whether antipsychotic response may be altered depending on the synaptic connectivity. We tested this association using polymorphisms in the neurexin 1 gene (NRXN1). Large NRXN1 deletions have also been associated with schizophrenia. We genotyped four variants in 140 schizophrenia patients assessed prospectively for clozapine response after 6 months. We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication.
精神分裂症患者表现出突触连接的改变。然而，抗精神病药物反应是否会因突触连接而改变仍不清楚。我们使用神经纤连蛋白1基因（NRXN1）的多态性来测试这种关联。大的NRXN1缺失也与精神分裂症有关。我们对140名精神分裂症患者的四个变体进行了基因分型，这些患者在6个月后接受了氯氮平反应的前瞻性评估。我们观察到氯氮平反应与rs12467557存在关联趋势（置换p = 0.051）。在进行独立验证之前，应谨慎解读这些结果。
