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CYP1A2 多态性与精神分裂症患者氯氮平所致不良反应的相关性。

Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.

机构信息

Department of Clinical Medicine- Section Clinical and Experimental Pharmacology, University of Insubria, Via Otorino Rossi 9, 21100 Varese, Italy.

出版信息

Psychiatry Res. 2012 Dec 30;200(2-3):1014-7. doi: 10.1016/j.psychres.2012.07.002. Epub 2012 Aug 16.

DOI:10.1016/j.psychres.2012.07.002
PMID:22901441
Abstract

We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2(⁎)1C and (⁎)1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).

摘要

我们研究了 CYP1A2（CYP1A2(⁎)1C 和 (⁎)1F）常见多态性与氯氮平（CLZ）诱导的不良反应（ADR）之间的关系，共纳入 34 名患者。有 ADR 的患者 CYP1A2 低活性等位基因组合的频率更高（8/12；67%），CYP1A2-mRNA 水平更低（6/22；27%，P=0.019）。

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