Department of Molecular Microbiology & Immunology, University of Southern California, Los Angeles, CA 90033, USA.
Future Microbiol. 2010 Sep;5(9):1349-65. doi: 10.2217/fmb.10.105.
Persistent viral infections are often associated with serious diseases, primarily by altering functions of the host immune system. The hallmark of Kaposi's sarcoma-associated herpesvirus (KSHV) infection is the establishment of a life-long persistent infection, which leads to several clinical, epidemiological and infectious diseases, such as Kaposi's sarcoma, a plasmablastic variant of multicentric Castleman's disease, and primary effusion lymphoma. To sustain an efficient life-long persistency, KSHV dedicates a large portion of its genome to encoding immunomodulatory proteins that antagonize the immune system of its host. In this article, we highlight the strategies KSHV uses to evade, escape and survive its battle against the host's immune system.
持续性病毒感染通常与严重疾病有关，主要是通过改变宿主免疫系统的功能。卡波西肉瘤相关疱疹病毒（KSHV）感染的标志是建立终身持续性感染，导致几种临床、流行病学和传染病，如卡波西肉瘤、多中心Castleman 病的浆细胞样变体和原发性渗出性淋巴瘤。为了维持有效的终身持续性，KSHV 将其基因组的很大一部分专门用于编码免疫调节蛋白，这些蛋白拮抗宿主的免疫系统。在本文中，我们强调了 KSHV 用来逃避、逃脱和生存其与宿主免疫系统对抗的策略。
