Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
J Med Virol. 2010 Mar;82(3):400-6. doi: 10.1002/jmv.21715.
Kaposi's sarcoma-associated herpesvirus (KSHV) is related causally to Kaposi's sarcoma, primary effusion lymphoma, and a subset of cases of multicentric Castleman's disease. As the numbers of acquired immunodeficiency syndrome (AIDS) patients have increased, KSHV-associated diseases have also increased in Japan. Sporadic cases of classic Kaposi's sarcoma have also been reported in Japan. In the present study, the clinicopathological characteristics of 75 samples, comprising 68 cases of Kaposi's sarcoma, 5 cases of primary effusion lymphoma, and 5 cases of multicentric Castleman's disease were investigated. All of these cases were positive for KSHV by immunohistochemistry or PCR analysis. All fifty-two of the AIDS-associated Kaposi's sarcoma cases were males, whereas 7 of the 13 non-AIDS-associated Kaposi's sarcoma cases were females. The mean age of patients with AIDS-associated Kaposi's sarcoma or primary effusion lymphoma was 46 years, whereas the mean age of patients with non-AIDS-associated Kaposi's sarcoma or primary effusion lymphoma was 71.8 and 97.5, respectively. KSHV genotypes were determined based on the sequence of variable region 1 in the K1 gene. Genotypes A and C of KSHV were detected in both AIDS- and non-AIDS-associated Kaposi's sarcoma. Genotype A was detected more frequently in AIDS-associated cases than non-AIDS-associated cases, suggesting that genotype C is broadly distributed in Japan, and genotype A spreads among AIDS patients. Genotype D was detected only in non-AIDS-associated Kaposi's sarcoma. These data confirmed the difference between AIDS- and non-AIDS-associated KSHV diseases with regard to age of onset, gender, and genotypes in Japan. J. Med. Virol. 82:400-406, 2010. (c) 2010 Wiley-Liss, Inc.
卡波济肉瘤相关疱疹病毒（KSHV）与卡波济肉瘤、原发性渗出性淋巴瘤以及部分多发性中心性 Castleman 病有因果关系。随着获得性免疫缺陷综合征（AIDS）患者数量的增加，日本 KSHV 相关疾病的数量也有所增加。日本也有散发性经典卡波济肉瘤的报道。本研究对 68 例卡波济肉瘤、5 例原发性渗出性淋巴瘤和 5 例多发性中心性 Castleman 病的 75 例样本的临床病理特征进行了研究。所有这些病例均通过免疫组化或 PCR 分析检测到 KSHV 阳性。52 例 AIDS 相关卡波济肉瘤病例均为男性，而 13 例非 AIDS 相关卡波济肉瘤病例中有 7 例为女性。AIDS 相关卡波济肉瘤或原发性渗出性淋巴瘤患者的平均年龄为 46 岁，而非 AIDS 相关卡波济肉瘤或原发性渗出性淋巴瘤患者的平均年龄分别为 71.8 岁和 97.5 岁。根据 K1 基因可变区 1 的序列确定 KSHV 基因型。在 AIDS 和非 AIDS 相关卡波济肉瘤中均检测到 KSHV 基因型 A 和 C。在 AIDS 相关病例中，基因型 A 的检出率高于非 AIDS 相关病例，提示基因型 C 在日本广泛分布，而基因型 A 在 AIDS 患者中传播。仅在非 AIDS 相关卡波济肉瘤中检测到基因型 D。这些数据证实了日本 AIDS 和非 AIDS 相关 KSHV 疾病在发病年龄、性别和基因型方面存在差异。J. Med. Virol. 82:400-406, 2010.（c）2010 Wiley-Liss, Inc.
