Kozul Darija, Romanić Snjezana Herceg
Institut za medicinska istrazivanja i medicinu rada, Zagreb, Hrvatska.
Arh Hig Rada Toksikol. 2010 Sep;61(3):339-56. doi: 10.2478/10004-1254-61-2010-2007.
This review presents the findings on the distribution and levels of 20 congeners of polychlorinated biphenyls (PCBs) and 7 organochlorine pesticides (OCPs) all over the world, based on measurements in samples of air, human milk and pine needles. The Institute for Medical Research and Occupational Health has been conducting research in all three matrices for many years, and this review summarises its results too. Significant decrease in concentrations of organochlorine compounds has been seen after the legal ban of their use, but that decresing trend has been slowed down and they are still found in all samples. In general, higher PCB levels are found in samples from urban locations, pesticides levels are higher in samples from locations where has been their probable usage in agriculture, while HCB levels are usually indicator of industrial activity.γ-HCH has been found in the highest concentration in air and pine needles samples, while in humans DDE and β-HCH are the most abundant compounds. Indicator PCB congeners are also differently present in environment and humans: in air and pine needles lower-chlorinated, more volatile PCB congeners have higher concentrations while in humans that goes for more persistent higher-chlorinated PCB congeners. Among toxic ortho-substituted PCB congeners in human and environmental samples the most abundant is PCB-118 while three non-ortho substituted congeners (PCB-77, PCB-126 and PCB-169) that are the most toxic ones are rarely detected. From organochlorine pesticides, DDD is found in lowest concentrations in all samples.
本综述基于对空气、母乳和松针样本的测量结果,介绍了多氯联苯(PCBs)20种同系物和7种有机氯农药(OCPs)在全球的分布及含量情况。医学研究与职业健康研究所多年来一直在这三种基质中开展研究,本综述也总结了其研究结果。自有机氯化合物被依法禁用后,其浓度显著下降,但下降趋势有所放缓,且在所有样本中仍可检测到。总体而言,城市地区样本中的多氯联苯含量较高,农业中可能使用过农药的地区样本中的农药含量较高,而六氯苯含量通常是工业活动的指标。γ-六氯环己烷在空气和松针样本中的浓度最高,而在人体中,滴滴滴和β-六氯环己烷是含量最丰富的化合物。指示性多氯联苯同系物在环境和人体中的存在情况也有所不同:在空气和松针中,低氯、挥发性更强的多氯联苯同系物浓度较高,而在人体中,情况则是持久性更强的高氯多氯联苯同系物含量较高。在人类和环境样本中的有毒邻位取代多氯联苯同系物中,含量最丰富的是多氯联苯-118,而三种毒性最强的非邻位取代同系物(多氯联苯-77、多氯联苯-126和多氯联苯-169)很少被检测到。在所有有机氯农药样本中,滴滴滴的浓度最低。