Yan Z Y
First Hospital of Beijing Medical University.
Zhonghua Wai Ke Za Zhi. 1990 May;28(5):298-301, 319.
The authors observed the effects of Radix Salviae Miltiorrhizae (RSM, Dan-shen) on gastric mucosa of twelve dogs with ex vivo gastric chambers. It was demonstrated that in physiological condition RSM increases gastric mucosal blood flow and potential difference, and decreased hydrogen ion back-diffusion. In this way, RSM kept the integrity of mucosal barrier, and improved its defence function. In pathological condition caused by aspirin, however, RSM could only delay the advance of mucosal lesions. According to this observation, RSM may be used as a prophylactic medicine combined with cimetidine in critical ill patients.
作者通过离体胃腔观察了丹参对12只犬胃黏膜的影响。结果表明，在生理状态下，丹参可增加胃黏膜血流量和电位差，减少氢离子反向弥散。通过这种方式，丹参保持了黏膜屏障的完整性，增强了其防御功能。然而，在阿司匹林所致的病理状态下，丹参只能延缓黏膜病变的进展。根据这一观察结果，丹参可与西咪替丁联合用作危重病患者的预防用药。
