Zhou S Y
Division of Pulmonary Diseases, First Affiliated Hospital of Harbin Medical University, Harbin.
Zhonghua Jie He He Hu Xi Za Zhi. 1990 Apr;13(2):99-101, 127-8.
We have observed the influence of Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum on the elastase activity and the protective effects of the two medicines on the elastic fibers. The results showed that Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum can inhibit the activity of porcine pancreatic elastase and human sputum elastase. These two drugs can protect arterial and pulmonary elastic fibers from the destruction of elastase. Since these traditional Chinese herbs have little toxic effect and no antigenic character, they can be used in the preventing emphysema. The study suggest that it is useful Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum are as favourable elastase inhibiting agents, which may be used in the prevention of emphysema extensively.
我们观察了丹参和盐酸川芎嗪对弹性蛋白酶活性的影响以及这两种药物对弹性纤维的保护作用。结果表明，丹参和盐酸川芎嗪能够抑制猪胰弹性蛋白酶和人痰液弹性蛋白酶的活性。这两种药物可以保护动脉和肺弹性纤维免受弹性蛋白酶的破坏。由于这些传统中药毒性小且无抗原性，它们可用于预防肺气肿。该研究表明，丹参和盐酸川芎嗪作为良好的弹性蛋白酶抑制剂是有用的，可广泛用于肺气肿的预防。
