Zou S Q
Tongji Hospital Tongji Medical University, Wuhan.
Zhonghua Wai Ke Za Zhi. 1990 Sep;28(9):536-8, 573.
In this study, 167 white rabbits were divided into 5 groups to observe the effects of biliary stricture and infection on the formation of bile duct stones and the pathophysiological changes of the biliary tract. It was found that there was a gradient of static hydraulic pressure along biliary tract and the pressure was directly proportional to hepatic blood flow. In the rabbits with bile duct stone formation, the activity of SDH, ATP ase and glycogen (PAS) in the mucosa of biliary tract was low and that of LDH was high. In the biliary tract wall damaged by infection and choledocholithiasis, a frame work consisting of polysaccharide protein, mucin, and mucoid polymer was observed and the authors considered it as one of causing factors in the formation of the stones.
在本研究中，167只白兔被分为5组，以观察胆管狭窄和感染对胆管结石形成的影响以及胆道的病理生理变化。研究发现，沿胆道存在静水压梯度，且该压力与肝血流量成正比。在形成胆管结石的兔子中，胆道黏膜中SDH、ATP酶和糖原（PAS）的活性较低，而LDH的活性较高。在因感染和胆总管结石而受损的胆道壁中，观察到由多糖蛋白、粘蛋白和类粘液聚合物组成的框架结构，作者认为这是结石形成的致病因素之一。
