Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
Vet Pathol. 2011 Jul;48(4):823-6. doi: 10.1177/0300985810382091. Epub 2010 Sep 22.
A 4-year-old spayed female Golden Retriever was presented for evaluation of a rostral maxillary gingival mass. An en bloc resection was performed after histologic diagnosis of ameloblastic fibroma from an incisional biopsy specimen. Histologically, the tumor was composed of (1) poorly differentiated vimentin-positive mesenchymal cells that surrounded islands and (2) thin anastomosing trabeculae of odontogenic epithelium that variably coexpressed pancytokeratin and vimentin. To the authors' knowledge, this is the first report of ameloblastic fibroma in a dog. The clinical, radiographic, and histologic findings in this case are compared to those in other domestic animals and humans.
一只 4 岁已去势的雌性金毛寻回猎犬因上颚牙龈肿块而就诊。组织学诊断为牙源性纤维瘤的切开活检标本后进行了整块切除术。组织学上,肿瘤由(1)表达波形蛋白的分化不良间充质细胞,这些细胞围绕岛状结构排列,(2)牙源性上皮的薄吻合小梁组成,这些小梁不同程度地共表达细胞角蛋白和波形蛋白。据作者所知,这是首例犬牙源性纤维瘤的报道。本病例的临床、影像学和组织学表现与其他家畜和人类的表现进行了比较。