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[冠心病血瘀证血小板吞噬作用]

[Phagocytosis of platelet in coronary heart disease with blood-stasis syndrome].

作者信息

Wu J

机构信息

Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 1990 Oct;18(5):273-5, 319.

PMID:2086190
Abstract

Thirty six healthy people and 64 coronary heart disease (CHD) patients with blood-stasis syndrome (BSS) were studied on the phagocytosis of platelets under electron microscope. The results showed that the number of latex particles which were phagocytized by platelet and the number of platelets which phagocytized the latex particles were all decreased markedly in CHD patients with BSS. It also showed that most of the platelets with active phagocytosis were in moderate-size. The proportion of big platelets and the platelets containing a large number of glycogen particles were much more in CHD patients with BSS. The platelets in CHD patients change their shapes readily with active exocytosis and aggregation. Therefore, it was considered that the abnormalities of some roles of platelets might be the basic changes in CHD with BSS.

摘要

对36名健康人和64名患有血瘀证的冠心病(CHD)患者进行了血小板吞噬作用的电镜研究。结果显示,患有血瘀证的冠心病患者中,被血小板吞噬的乳胶颗粒数量以及吞噬乳胶颗粒的血小板数量均显著减少。还显示,大多数具有活跃吞噬作用的血小板为中等大小。患有血瘀证的冠心病患者中,大血小板以及含有大量糖原颗粒的血小板比例更高。冠心病患者的血小板容易随着活跃的胞吐作用和聚集而改变形状。因此,认为血小板某些功能的异常可能是患有血瘀证的冠心病的基本变化。

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