Wu J, Chen K J, Wu Y J
Department of Clinical Pharmacology, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Chin Med J (Engl). 1993 Jul;106(7):546-9.
Phagocytosis of platelets was studied under electronmicroscope in 36 healthy persons and 64 coronary heart disease (CHD) patients with blood-stasis syndrome (BSS). The result showed that both the number of latex particles phagocytized by platelet and platelets which phagocytized latex particles were decreased in CHD with BSS. It was also found in this group that most of the platelets having active-phagocytosis were of medium size. The proportion of large platelets containing plentiful glycogen granules was much more in CHD patients with BSS and the shapes of platelets were changed readily with active exocytosis and aggregations. Therefore the present findings of disability of platelet phagocytosis might be considered the basic change in CHD with BSS.
在电子显微镜下研究了36名健康人和64例冠心病血瘀证患者的血小板吞噬作用。结果显示，冠心病血瘀证患者中被血小板吞噬的乳胶颗粒数量以及吞噬乳胶颗粒的血小板数量均减少。该组还发现，大多数具有活跃吞噬作用的血小板为中等大小。冠心病血瘀证患者中含有丰富糖原颗粒的大血小板比例更高，且血小板形态容易因活跃的胞吐作用和聚集而改变。因此，目前血小板吞噬功能障碍的研究结果可能被认为是冠心病血瘀证的基本变化。
