Cherchi P L, Campiglio A, Rubattu A, Desole A, Andria G, Ambrosini A
Gynaecologic and Obstetric Institute, University of Sassari.
Eur J Gynaecol Oncol. 1990;11(6):477-9.
Thirteen patients with malignant genital or mammary neoplasias, with endocavitary neoplastic effusion (pleural or ascitic), were examined in order to study the modifications of neoplastic effusion in endocavitary treatment (intrapleural or intraperitoneal) with Beta-Interferon. There was an overall objective response in 70% of the patients treated, with 53.8% complete responses and an average duration response of above 6 months. The best results were obtained in patients with ovarian cancer, with 75% of objective responses (50% CR), confirming the efficacy of Beta-Interferon particularly at peritoneal level, where there is higher concentration and exposure of the drug in the site of disease.
对13例患有恶性生殖器或乳腺肿瘤且伴有腔内肿瘤性积液（胸腔积液或腹水）的患者进行了检查，以研究使用β-干扰素进行腔内治疗（胸腔内或腹腔内）时肿瘤性积液的变化。接受治疗的患者总体客观缓解率为70%，完全缓解率为53.8%，平均缓解持续时间超过6个月。卵巢癌患者取得了最佳结果，客观缓解率为75%（完全缓解率为50%），证实了β-干扰素的疗效，尤其是在腹膜层面，该药物在疾病部位的浓度和暴露程度更高。
