胸膜内注射天然β干扰素治疗恶性胸腔积液

Intrapleural natural beta interferon in the treatment of malignant pleural effusions.

作者信息

Rosso R, Rimoldi R, Salvati F, De Palma M, Cinquegrana A, Nicolò G, Ardizzoni A, Fusco U, Capaccio A, Centofanti R

机构信息

Dipartimenti di Oncologia Medical e Anatomia Patologica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italia.

出版信息

Oncology. 1988;45(3):253-6. doi: 10.1159/000226571.

DOI:10.1159/000226571

PMID:2453008

Abstract

Effusion recurrence is a major problem in the palliative care of patients with disseminated cancer. Thirty-two patients with recurrent malignant pleural effusions were treated with intracavitary natural beta-interferon at increasing doses (5-20 million units) for a maximum of three administrations. Among 29 evaluable patients, 11 showed complete (27.6%) or partial (10.3%) remission. No difference in response rate was observed according to sex, age, and histological type. All the responses were observed in patients with an effusion volume less than 1,000 ml (11/16; 68.8%). No side effect was observed. In conclusion, intrapleural beta-interferon is promising as a palliative in the treatment of recurrent malignant effusions.

摘要

积液复发是晚期癌症患者姑息治疗中的一个主要问题。32例复发性恶性胸腔积液患者接受了腔内注射天然β-干扰素治疗，剂量逐渐增加（500 - 2000万单位），最多注射3次。在29例可评估患者中，11例出现完全缓解（27.6%）或部分缓解（10.3%）。根据性别、年龄和组织学类型未观察到缓解率的差异。所有缓解均出现在积液量小于1000 ml的患者中（11/16；68.8%）。未观察到副作用。总之，胸膜内注射β-干扰素在复发性恶性积液的治疗中作为一种姑息治疗方法很有前景。