不对称烯丙基烷基化反应与闭环复分解反应相结合，用于制备手性 N-杂环化合物。
Asymmetric allylic alkylation in combination with ring-closing metathesis for the preparation of chiral N-heterocycles.
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
出版信息
Org Lett. 2010 Oct 15;12(20):4658-60. doi: 10.1021/ol101944j.
PMID:20863080
Abstract
Asymmetric copper-catalyzed allylic substitution with methylmagnesium bromide is employed in combination with ring-closing olefin metathesis or ene-yne metathesis to achieve the synthesis of chiral, unsaturated nitrogen heterocycles. The resulting six- to eight-membered chiral heterocycles are accessible in high yields and with excellent enantioselectivities.
摘要
不对称铜催化的烯丙基取代反应与甲基溴化镁结合使用，与闭环烯烃复分解或烯炔复分解反应相结合，可实现手性、不饱和氮杂环的合成。所得的六至八元手性杂环以高产率和优异的对映选择性获得。
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