在铜和铱催化的不对称烯丙基烷基化反应中，作为环状底物的替代物，使用ω-乙基烯丙基亲电试剂。

Omega-ethylenic allylic substrates as alternatives to cyclic substrates in copper- and iridium-catalyzed asymmetric allylic alkylation.

机构信息

Department of Organic Chemistry, University of Geneva, 30, quai Ernest Ansermet CH-1211, Geneva 4, Switzerland.

出版信息

Org Lett. 2010 Mar 19;12(6):1156-9. doi: 10.1021/ol100162y.

PMID:20166707

Abstract

A new strategy to access highly enantioenriched cyclic compounds (up to 98%) is proposed using omega-ethylenic allylic substrates through a one-pot asymmetric allylic alkylation and ring-closing metathesis. Such starting compounds can be seen as synthetic equivalents of cyclic allylic substrates.

摘要

提出了一种新策略，通过一锅不对称烯丙基烷基化和环化复分解反应，使用ω-烯丙基烯丙基底物来获得高对映体富集的环状化合物（高达 98%）。这种起始化合物可以被视为环状烯丙基底物的合成等价物。