Wiegratz Inka, Galiläer Katrin, Sänger Nicole, Rody Achim, Kuhl Herbert, Schleussner Ekkehard
Centre of Obstetrics and Gynaecology, Department of Gynaecological Endocrinology and Reproductive Medicine, University Hospital of Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.
Eur J Contracept Reprod Health Care. 2010 Dec;15(6):405-12. doi: 10.3109/13625187.2010.518708. Epub 2010 Sep 24.
To investigate prescribing preferences and personal experience of female gynaecologists with extended-cycle use of combined oral contraceptives (COCs) in Germany and Austria.
A questionnaire on prescribing patterns and personal experience with extended COC regimens was delivered to female gynaecologists practising in Germany and Austria.
Of 2,500 delivered questionnaires, 1,113 were returned. After exclusion of 22 invalid questionnaires, the remaining 1,091 (43.6% of delivered questionnaires) remained eligible for analysis and were considered as the full analysis set (100%). Nearly all gynaecologists (97%) reported prescription of extended-cycle regimens to their patients, independent of their personal experience as users. The main medical reasons for prescription were cycle-related headache (93.8%), dysmenorrhoea (88.2%), cycle-related complaints (74.5%), and hypermenorrhoea (70.9%). In total, 863 gynaecologists had personally used COCs, 321 (37.2%) in extended-cycle regimen. The most commonly employed combinations were 30 μg ethinylestradiol (EE) + 2 mg dienogest (n = 114; 37.5%) and 30 μg EE + 3 mg drospirenone (n = 69; 22.7%).
Although considered off-label use, extended-cycle use of COCs is widely prescribed and personally used by German and Austrian female gynaecologists. The lack of personal experience with extended-cycle use does not impair the prescribing habit of gynaecologists with regard to extended-cycle regimens.
调查德国和奥地利女性妇科医生在延长周期使用复方口服避孕药（COC）方面的处方偏好和个人经验。
向在德国和奥地利执业的女性妇科医生发放一份关于延长周期COC方案的处方模式和个人经验的问卷。
在发放的2500份问卷中，回收了1113份。排除22份无效问卷后，其余1091份（占发放问卷的43.6%）仍符合分析条件，被视为完整分析集（100%）。几乎所有妇科医生（97%）都报告为患者开具了延长周期方案的处方，无论其个人作为使用者的经验如何。处方的主要医学原因是与周期相关的头痛（93.8%）、痛经（88.2%）、与周期相关的不适（74.5%）和月经过多（70.9%）。共有863名妇科医生个人使用过COC，其中321名（37.2%）采用延长周期方案。最常用的组合是30μg炔雌醇（EE）+2mg地诺孕素（n=114；37.5%）和30μg EE+3mg屈螺酮（n=69；22.7%）。
尽管延长周期使用COC被视为超说明书用药，但德国和奥地利的女性妇科医生广泛开具此类处方并个人使用。缺乏延长周期使用的个人经验并不影响妇科医生在延长周期方案方面的处方习惯。
