École Nationale Supérieure d'Agronomie et des Industries Alimentaires, Institut National Polytechnique de Lorraine, 2 Avenue de la Forêt de Haye, 54501 Vandoeuvre les Nancy, France.
Curr Drug Targets. 2011 Apr;12(4):531-45. doi: 10.2174/138945011794751582.
Today, liposomes are one of the most effective carriers systems employed in biological, pharmaceutical, medical and nutritional research. In order to optimize a liposomal formulation for the encapsulation, delivery and release of the entrapped material, it is necessary to study material passage through the lipidic and aqueous phases of the lipid vesicle. Towards this end, this article aims to review the mechanisms of bioactive transfer between different layers of a liposome and it also discusses about the bioactive release mechanism. Several methods of detection and observation of bioactive transfer in liposomal systems are presented.
如今，脂质体是生物、制药、医学和营养研究中使用的最有效的载体系统之一。为了优化脂质体的封装、传递和释放包封材料的配方，有必要研究物质通过脂质体的脂质相和水相的传递。为此，本文旨在综述生物活性物质在脂质体各层之间传递的机制，并讨论生物活性物质的释放机制。本文还介绍了几种检测和观察脂质体系统中生物活性物质传递的方法。
